Selenium Nanoplatform Engages Tranexamic Acid to Alleviate Ultraviolet B-Induced Skin Pigmentation via Inflammatory Response.

Abstract

Skin is the largest organ of the body and serves as a barrier against various environmental threats, including ultraviolet (UV) radiation, which could lead to pigmentation and an increased risk of melanoma. Oxidative stress has been identified as a significant factor in UV-induced skin pigmentation, yet there still remain significant challenges in understanding its role <i>in vivo</i>. Selenium nanoparticles have exhibited multiple bioactivities in many fields, but their application in skin diseases is limited. In this work, the zebrafish screen was first carried out in a transgene zebrafish larva cocultured with Nano-Se, which demonstrated a whitening effect of Nano-Se on pigmentation caused by UVB exposure <i>in vivo</i>. Further study showed that Nano-Se could also boost the effectiveness of tranexamic acid, combined with the whitening effect in relieving UVB-induced skin pigmentation and damage in mice. In a word, the Nano-Se described in this study offers an efficient and practical approach for synthesizing bioactive selenium nanoplatforms, broadening the application of nanoselenium to combat UVB-induced skin damage, and potentially revitalizing research of nanoselenium in various human diseases.