Reducing PTP1B in the Hippocampus Protects Against Cognitive Decline in Prediabetes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40638402.
- Also identified by DOI 10.2337/db24-1167.
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Abstract
The present study reveals a previously unknown molecular mechanism linking prediabetes to neurodegeneration, addressing a critical gap in understanding metabolic-neurological interplay. We investigated whether PTP1B mediates prediabetes-induced cognitive impairment. PTP1B impaired synaptic signaling and synaptic ultrastructure in hippocampal neurons, contributing to cognitive decline in prediabetes. PTP1B is a novel therapeutic target for prediabetes-associated neurodegeneration.
Medical subject headings
- Hippocampus
- Prediabetic State
- Protein Tyrosine Phosphatase, Non-Receptor Type 1
- Cognitive Dysfunction