Multiorgan transcriptomics in mice identifies immunoglobulin heavy constant mu (<i>Ighm</i>) as a tissue-level aging biomarker.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40643973.
- Also identified by DOI 10.1073/pnas.2423142122 and PMC identifier 12280941.
- Licence recorded as CC BY-NC-ND.
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Abstract
Identifying aging-associated biomarkers applicable for multiple tissues is challenging but crucial for assessing tissue aging. Here, we obtained and analyzed 456 transcriptomes on 17 organs from 30 C57BL/6 J mice with different ages, revealing the consistently upregulated mRNAs of <i>Ighm</i>, <i>C4b</i>, and <i>Ccl8</i> in most aged organs. This finding received support from independent transcriptomic and proteomic datasets and was further validated through western blot, enzyme-linked immunosorbent assay (ELISA), and immunofluorescence, arguing for both <i>Ighm</i> mRNA and protein as tissue-level aging biomarkers, at least in mice. Its sensitivity to antiaging interventions further emphasizes the significance of <i>Ighm</i> in assessing tissue aging in mice.
Medical subject headings
- Aging
- Transcriptome
- Immunoglobulin Heavy Chains