68 Ga-Pentixafor Uptake in Collecting Duct Carcinoma.

Yang, Juan; Pang, Shangjing; Zhang, Chunfang; Xie, Yang; Chen, Yue · Clin Nucl Med · 2026

case_report · Level V

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Abstract

Collecting duct carcinoma (CDC), also known as Bellini duct carcinoma, is a highly aggressive and extremely rare subtype of renal cell carcinoma. Previous studies have suggested that CDC generally exhibits low CXCR4 expression, leading to negative or weak 68 Ga-pentixafor uptake. However, we report a case of 68 Ga-Pentixafor uptake in CDC on PET/CT. This finding challenges the conventional understanding of chemokine characteristics in CDC and underscores the importance of tumor heterogeneity, potentially providing new insights for precision treatment strategies.

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