Burst firing in Alzheimer's disease: A shift beyond amyloid?
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 40645166.
- Also identified by DOI 10.1016/j.cell.2025.06.016.
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Abstract
In this issue of Cell, Harris et al. reveal that high-molecular-weight soluble tau-rather than amyloid-beta-impairs burst firing in hippocampal neurons, providing a mechanistic link to cognitive decline in Alzheimer's disease. This disruption, linked to CaV2.3 downregulation, highlights soluble tau as a key driver of neuronal dysfunction and a promising therapeutic target.
Medical subject headings
- Alzheimer Disease
- tau Proteins
- Neurons