Etilefrine: A Novel Treatment for Refractory, Life-Threatening Chylothorax in the Newborn.

Gilliot, Sixtine; Le Duc, Kévin; Chopinet, Caroline; Décaudin, Bertrand; Odou, Pascal; Storme, Laurent; Riadh Boukhris, Mohamed · Pediatrics · 2025

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Abstract

There are few evidence-based treatment options for chylothorax in newborns. We report on 5 cases of preterm newborn infants who received drainage and continuous etilefrine infusion for clinically significant, refractory chylothorax. Irrespective of the cause of the effusion, etilefrine infusion was associated with a clear decrease in chylous output within 2 to 4 days of initiation with heart rates and blood pressures maintained within the age-normal limits.

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