The emerging era of structural nanomedicine.

Mirkin, Chad A; Mrksich, Milan; Artzi, Natalie · Nat Rev Bioeng · 2025

basic_science · Level V

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Abstract

The lack of structural definition in nanomedicines limits therapeutic efficacy and complicates regulatory approval. Here, we emphasize that defining, designing and optimizing the structures of nanomedicine are critical to developing effective therapies because their architectures - not just the identity of their components - determines potency.