Long-Term Outcomes and Social Reintegration After Salvage Open Partial Horizontal Laryngectomy Type II/III for Radiation Failure.

Abstract

The long-term outcomes and social reintegration following open partial horizontal laryngectomy (OPHL) type II/III after radiation failure remain unclear. This study aimed to evaluate the outcomes of salvage OPHL. We retrospectively analyzed 56 recurrent cases after radiotherapy and 84 unirradiated cases who underwent OPHL type II/III at Kitasato University Hospital between November 1997 and October 2023. Overall survival (OS), disease-free survival (DFS), larynx preservation (LP), laryngo-esophageal dysfunction-free survival (LEDFS), and return to work (RTW) were evaluated. At 10 years, OS, DFS, LP, and LEDFS were 76%, 73%, 93%, and 67% in recurrent cases and 65%, 58%, 94%, and 58% in unirradiated cases, with no significant difference. RTW rates were 87% and 81%, respectively (p = 0.57). OPHL type II/III after radiation failure demonstrated favorable long-term outcomes and RTW rates, supporting its role as a valuable salvage option.