The podocyte gets a pedicure: tiny nail clippers for podocyte foot processes.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 40685177.
- Also identified by DOI 10.1016/j.kint.2025.05.009.
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Abstract
Proteases, such as A disintegrin and metalloproteinase 10, can cleave the extracellular domains of transmembrane proteins and trigger a subsequent regulated intramembrane proteolysis step that releases the cytosolic domain into the cell. In this issue, Rosenbaum et al. unraveled the role of A disintegrin and metalloproteinase 10 in the podocyte by showing that it can release the ectodomains of the membranous nephropathy target antigens phospholipase A2 receptor 1 and thrombospondin type 1 domain-containing 7A as well as the adhesion molecule β-dystroglycan.
Medical subject headings
- Podocytes
- Glomerulonephritis, Membranous