Multiplicity Control in Clinical Trials.

LaLonde, Amy; Nissen, Steven E · NEJM Evid · 2025

review · Level V

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Abstract

AbstractStatistical testing of more than one hypothesis has the potential to increase the risk of wrongly concluding that the result for a given end point is statistically significant (false discovery). This review is designed to acquaint nonstatisticians with traditional approaches for controlling type I error and with the seemingly complex procedure known as graphical testing.

Medical subject headings