Virological Tools Fail to Properly Identify "Unusual" Hepatitis C Virus Subtypes Resistant to Direct-Acting Antiviral Drugs in The Gambia.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 40695563.
- Also identified by DOI 10.1093/infdis/jiaf378.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
We evaluated the ability of the commercial Sentosa SQ Hepatitis C Virus Genotyping Assay to identify the hepatitis C virus (HCV) genotype subtype in patients from The Gambia. Subtype was determined from the Sentosa-generated NS5B sequences using 3 bioanalytical methods: Sentosa SQ HCV Genotyping Assay bioanalytical tool, Geno2pheno, and the National Reference Center in-house method. The Sentosa assay result agreed with the reference method in only 2 of 13 cases. This study highlights the difficulty of correctly identifying HCV subtypes in a region of Africa with a high diversity of HCV genotype 1 and 2 subtypes that may be resistant to antivirals.
Medical subject headings
- Hepacivirus
- Antiviral Agents
- Drug Resistance, Viral
- Hepatitis C
- Genotyping Techniques