Inverting the logic in amyotrophic lateral sclerosis.

Turner, Martin R · Brain · 2025

Level V

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Abstract

Turner highlights survivorship bias in the study of neurodegenerative disorders such as ALS, suggesting that meaningful progress may require a fundamental shift in focus from the affected to the resilient, and from what is seen to what is not. Neurodegeneration should be viewed as a loss of tolerance as much as a gain of toxicity.