Consequences of Stopping Antiretroviral Treatment in a Persistently Seronegative Individual with HIV-1.

Wirden, Marc; Guihot, Amelie; Gautheret-Dejean, Agnes; Sterlin, Delphine; Fayçal, Antoine; Cocherie, Theophile; Calvez, Vincent; Marcelin, Anne-Genevieve et al. · Clin Infect Dis · 2026

case_report · Level V

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Abstract

This case of HIV-1-seronegative infection due to very early treatment demonstrates that even in the absence of sufficient HIV replication to generate detectable immunity, a competent reservoir can accumulate, allowing replication to resume despite 20 months of effective treatment and the disappearance of molecular evidence of infection.

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