<i>Escherichia coli</i> with a 57-codon genetic code.
basic_science · Level V
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- Record sourced from PubMed, PMID 40743368.
- Also identified by DOI 10.1126/science.ady4368.
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Abstract
The near-universal genetic code uses 64 codons to encode the 20 canonical amino acids and protein synthesis. Here, we designed and generated <i>Escherichia coli</i> with a 4-megabase synthetic genome in which we replaced known occurrences of six sense codons and a stop codon with synonymous codons. The resulting organism, Syn57, uses 55 codons to encode the 20 canonical amino acids.
Medical subject headings
- Codon
- Escherichia coli
- Genes, Synthetic
- Genetic Code
- Protein Biosynthesis