Multiparameter optimal control of F_{1}-ATPase.
basic_science · Level V
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- Record sourced from PubMed, PMID 40745772.
- Also identified by DOI 10.1103/bm3d-c67v.
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Abstract
Biological molecular machines convert free energy between different forms in cells, often at high efficiency. Optimal control theory provides a framework to elucidate design principles governing energetically efficient driving. Here, we use linear-response theory to design efficient protocols exercising dynamic control of trap center and stiffness in a model of driven F_{1}-ATPase. We find that the key design principles of an efficient protocol can be satisfied either by dynamic control of both parameters or by dynamic control of a single parameter and a good static choice for the second. These results illustrate that accessing a new degree of dynamic control provides varying performance improvements in different systems.