Design specifications for biomedical virtual twins in engineered adoptive cellular immunotherapies.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 40750653.
- Also identified by DOI 10.1038/s41746-025-01809-6 and PMC identifier 12316993.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
In (immune)oncology, virtual twins (VTs) offer patient-individual decision support. Nevertheless, current VTs do not incorporate the unique properties of engineered adoptive cellular immunotherapies (eACIs). Here, we outline the minimal design specifications for VTs for engineered ACIs (eACI-VTs) to model the complex interplay between cell product and patient physiology. We motivate utilizing VTs in eACIs to provide decision support and reflect on how eACI-VTs can support the widespread use of eACIs.