Rotation-invariance is essential for accurate detection of spatially variable genes in spatial transcriptomics.
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- Record sourced from PubMed, PMID 40753081.
- Also identified by DOI 10.1038/s41467-025-62574-4 and PMC identifier 12318016.
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Abstract
In spatial transcriptomics, tissue samples are randomly positioned. Rotation-sensitive methods can lead to unreliable spatially variable gene (SVG) detection. We highlight their inherent technical pitfalls and discuss strategies for rotation-invariant methods, enhancing the robustness of SVG detection.