Skeletal editing of pyridines to aryldialdehydes.
basic_science · Level V
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- Record sourced from PubMed, PMID 40759905.
- Also identified by DOI 10.1038/s41467-025-62627-8 and PMC identifier 12322128.
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Abstract
Electron-deficient nitrogen-containing aromatic heterocycles, particularly pyridine derivatives, can be converted into all-carbon aromatic frameworks via the ANRORC (Addition of Nucleophile, Ring-Opening, and Ring-Closing) skeletal editing process, providing a convenient tool for molecular diversification. However, reported methods are mainly limited to nucleophilic modification of ring-opening species. Herein, we report a distinct electrophilic modification method, smoothly converting pyridines into arene-1,3-dialdehydes or naphthalene-1,3-dialdehydes.