Unexpected effects of semaglutide on skeletal muscle mass and force-generating capacity in mice.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40769122.
- Also identified by DOI 10.1016/j.cmet.2025.07.004.
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Abstract
Loss of lean mass is a potential concern for semaglutide-induced weight loss. This study indicates that semaglutide has unexpected effects on skeletal muscle mass and strength in mice, demonstrating a need to more carefully assess these effects in humans.
Medical subject headings
- Muscle, Skeletal
- Glucagon-Like Peptides
- Muscle Strength