Foam cell-derived exosomes: Messengers between atherosclerosis and microglia.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40769126.
- Also identified by DOI 10.1016/j.cmet.2025.07.005.
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Abstract
Atherosclerosis (AS) is an independent risk factor for vascular cognitive impairment (VCI). Zhang et al.<sup>1</sup> revealed that foam cell-derived exosomes transmit redox imbalance and metabolic defects to microglia via the miR-101-3p-Nrf2-Slc2a1 axis, causing microglial dysfunction and exacerbating VCI, uncovering a peripheral-brain link and potential therapeutic targets for AS-induced VCI.
Medical subject headings
- Exosomes
- Microglia
- Atherosclerosis
- Foam Cells