Insulin signaling in microglia: A metabolic switch controlling neuroinflammation and amyloid pathology in Alzheimer's disease.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40769128.
- Also identified by DOI 10.1016/j.cmet.2025.06.005.
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Abstract
Insulin resistance is a risk factor for Alzheimer's disease (AD). Chen et al.<sup>1</sup> show that microglial insulin signaling is essential for metabolic homeostasis and immune regulation, while insulin resistance impairs Aβ clearance and promotes neuroinflammation in AD. Their findings reframe AD pathogenesis through a cell-type-specific lens.
Medical subject headings
- Alzheimer Disease
- Microglia
- Insulin
- Neuroinflammatory Diseases