Glycogen shepherd guides the hidden trail of pentose phosphate pathway.
basic_science · Level V
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- Record sourced from PubMed, PMID 40769129.
- Also identified by DOI 10.1016/j.cmet.2025.07.002.
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Abstract
In a recent Molecular Cell study,<sup>1</sup> Zhou et al. elucidated how glycogenolysis-derived glucose-1-phosphate mediates source-specific routing of glucose-6-phosphate into the pentose phosphate pathway through allosteric activation of glucose-6-phosphate dehydrogenase and liquid-liquid phase separation-mediated metabolic compartments. This compartmentalized distribution enables efficient reduced nicotinamide adenine dinucleotide phosphate (NADPH) generation from glycogenolytic flux, promoting Tm cell persistence by maintaining redox homeostasis.
Medical subject headings
- Pentose Phosphate Pathway
- Glycogen