Enzymatic craftsmanship in collagen glycosylation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40770197.
- Also identified by DOI 10.1038/s41467-025-62768-w and PMC identifier 12328614.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Collagen IV, a key structural protein of basement membranes, is vital for the development and survival of multicellular life forms. Its maturation relies on specific post-translational O- glycosylation, primarily mediated by lysyl hydroxylase-3 (LH3) and other glycosyltransferases, which sculpt collagen by modifying the hydroxylysine residues with sugar moieties.