Arrestins and opioid-independent analgesia.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 40780184.
- Also identified by DOI 10.1016/j.cell.2025.07.008.
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Abstract
In this issue of Cell, Ji and colleagues describe the development of SBI-810, a β-arrestin-biased modulator of neurotensin receptor 1 (NTSR1). This compound provides potent analgesia in rodent models of acute and chronic pain without side effects. This study highlights the therapeutic potential of targeting arrestin-biased GPCR signaling for non-opioid pain management.
Medical subject headings
- Analgesia
- Arrestins