Plot twist: TET2 clones save the brain.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40780187.
- Also identified by DOI 10.1016/j.stem.2025.07.001.
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Abstract
While clonal hematopoiesis (CH) is associated with protection from Alzheimer's disease (AD), a limited understanding of the mechanisms by which this occurs has been a barrier to therapeutic intervention. In a new study, Matatall et al.<sup>1</sup> discover protective mechanisms by which TET2-mutant, but not DNMT3A-mutant, CH impacts dementia pathology and cognition.
Medical subject headings
- Brain
- Proto-Oncogene Proteins
- DNA-Binding Proteins