Letter to the editor concerning "CALM1 polymorphism in degenerative cervical myelopathy of the Indian cohort" by Maheshwari S et al. (Eur spine J [2025]: doi.org/10.1007/s00586-025-09090-7).

Abstract

We appreciate the efforts of Maheshwari et al. in exploring CALM1 polymorphisms in degenerative cervical myelopathy (DCM) within an Indian cohort. While the study offers valuable insights, we respectfully highlight certain methodological concerns-particularly regarding statistical interpretation, control group heterogeneity, and age differences between groups. Furthermore, interpretations suggesting pathogenicity for a computationally benign variant may benefit from additional functional validation. We believe that addressing these aspects in future studies will enhance the robustness and translational relevance of genetic research in DCM.