Severe Acute Localized Reaction/Pseudosepsis in Patients With Knee Osteoarthritis Receiving Injections of Hyaluronic Acid: A Targeted Literature Review.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 40788831.
- Also identified by DOI 10.3928/01477447-20250715-01.
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Abstract
Hyaluronic acid injections for knee osteoarthritis patients can result in pseudosepsis. A targeted literature review was conducted to determine the rate of pseudosepsis in patients receiving intra-articular hyaluronic acid, particularly hylan G-F 20 (SYNVISC<sup>®</sup>). Articles were identified through Embase using predefined search strategies. Pseudosepsis event rate was calculated by dividing the number of reported events by the total number of intra-articular injections. The pseudosepsis event rate ranged from 0% to 5.6% per injection; most treatment groups had an event rate of ≤2% per injection. Pseudosepsis event rates were low across studies for patients treated with hyaluronic acid, including hylan G-F 20.
Medical subject headings
- Hyaluronic Acid
- Osteoarthritis, Knee
Anatomy
- knee