PEELing: an integrated and user-centric platform for spatially resolved proteomics data analysis.
basic_science · Level V
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- Record sourced from PubMed, PMID 40794857.
- Also identified by DOI 10.1093/bioinformatics/btaf439 and PMC identifier 12343102.
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Abstract
Molecular compartmentalization is vital for cellular physiology. Spatially resolved proteomics allows biologists to survey protein composition and dynamics with subcellular resolution. Here, we present PEELing, an integrated package and user-friendly web service for analyzing spatially resolved proteomics data. PEELing assesses data quality using curated or user-defined references, performs cutoff analysis to remove contaminants, connects to databases for functional annotation, and generates data visualizations-providing a streamlined and reproducible workflow to explore spatially resolved proteomics data. PEELing and its tutorial are publicly available at https://peeling.janelia.org/ (Zenodo DOI: 10.5281/zenodo.15692517). A Python package of PEELing is available at https://github.com/JaneliaSciComp/peeling/ (Zenodo DOI: 10.5281/zenodo.15692434).
Medical subject headings
- Proteomics
- Software