Background HIV Incidence in PURPOSE 1 and 2 PrEP Trials.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 40810358.
- Also identified by DOI 10.1093/cid/ciaf436 and PMC identifier 12728266.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
HIV incidence among low-adherence oral PrEP users in PURPOSE 1 and 2 closely matched or slightly exceeded background HIV incidence (bHIV), supporting bHIV as a conservative comparator in PrEP trials. This enables ethical, efficient evaluation of new prevention strategies without placebo arm.
Medical subject headings
- HIV Infections
- Pre-Exposure Prophylaxis
- Anti-HIV Agents