Doxycycline post-exposure prophylaxis and off-target antimicrobial resistance: potential amplification within sexual networks.

Roberts, Manon; Davis, Peter · J Infect Dis · 2025

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Abstract

Doxycycline post-exposure prophylaxis (doxyPEP) is now included in many clinical guidelines, yet concerns remain regarding antimicrobial resistance (AMR), particularly off-target effects on commensal bacteria in the oropharynx, with intimate behaviours potentially facilitating resistance transmission within sexual networks.