Unusual 131 I Uptake in Talus May Reveal Distant Papillary Thyroid Cancer Metastasis With Anaplastic Transformation.

Wang, Guoqiang; Zhang, Yingying; Li, Jiao; Lu, Chenghui; Wang, Xufu · Clin Nucl Med · 2025

case_report · Level V

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Abstract

Talus metastasis is rarely observed on a 131 I whole-body scan (WBS). We report a case of abnormal 131 I uptake in the talus on the post-therapeutic WBS in a 54-year-old woman with papillary thyroid cancer (PTC). The patient received 2 courses of radioactive 131 I therapy (RAIT) after the thyroid surgery. WBS after the second dose of RAIT showed that 131 I uptake in the right talus declined than the last post-therapeutic WBS presented. The talus lesion was confirmed to be metastatic PTC with anaplastic transformation by pathologic examination and immunohistochemistry.

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