Precision Engineering of Bioceramics.

Abstract

Precision medicine aims to provide specific and personalized treatment strategies for patients, the realization of which depends highly on the integration of materials science and advanced biofabrication technologies. Bioceramics, as one of the typical biomaterials, have been widely used in biomedical fields due to their excellent bioactivity and biocompatibility. However, traditional "one-size-fits-all" fabrication of bioceramics falls short of meeting the demands of precision medicine. Recently, growing attention has been directed toward the precision design and fabrication of bioceramics. Therefore, this review proposed the concept of precision engineering of bioceramics, which encompasses personalized design and precise biofabrication. Initially, the key features of precision-engineered bioceramics are introduced. Then, recent advances in advanced biofabrication for bioceramics are systematically reviewed. Typical applications of precision-engineered bioceramics in tissue engineering and regenerative medicine are subsequently summarized. Finally, the current challenges and future directions are discussed. Overall, this review bridges the gap between conventional bioceramics and emerging biofabrication technologies, offering novel perspectives for the future development of bioceramic science and technologies.