DNA Methylation Biomarkers Predict Offspring Metabolic Risk From Mothers With Hyperglycemia in Pregnancy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40834241.
- Also identified by DOI 10.2337/db25-0105 and PMC identifier 12365412.
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Abstract
Maternal hyperglycemia is linked to 19 cord blood DNA methylation biomarkers that predict offspring metabolic dysfunction. These methylation changes, associated with maternal glycemic status, improved the prediction of β-cell dysfunction at 7, 11, and 18 years of age compared with clinical factors alone. Validation in human β-cells and pancreatic ductal epithelial cells confirmed that hyperglycemia influences methylation-dependent gene expression. These findings highlight the role of epigenetic modifications at birth as early indicators of diabetes risk, suggesting that in utero hyperglycemic exposure may mediate long-term metabolic outcomes in offspring.
Medical subject headings
- DNA Methylation
- Hyperglycemia
- Prenatal Exposure Delayed Effects
- Diabetes, Gestational