Cardiovascular-kidney-metabolic syndrome: A new frontier or simple rebranding?

Manne-Goehler, Jennifer; Venter, Willem Daniel Francois; Ali, Mohammed K; Franco, Juan V A · PLoS Med · 2025

review · Level V

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Abstract

Cardiovascular-kidney-metabolic (CKM) syndrome is an emerging framework proposed by the American Heart Association for management of patients with cardio-metabolic multimorbidity. This novel framework offers several improvements over existing paradigms; however, it remains unclear whether it represents a new frontier, or a simple rebranding of known clinical principles.

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