Evolution of Hepatitis A-Related Acute Liver Failure in North America Over 22 years.
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 40844518.
- Also identified by DOI 10.14309/ajg.0000000000003743.
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Abstract
Hepatitis A virus (HAV) is a rare cause of acute liver failure (ALF) that carries a relatively good prognosis for recovery. In recent years, overall numbers of HAV cases have declined, likely because of increased hepatitis A vaccination rates. We reviewed the Acute Liver Failure Study Group registry for the number HAV-related ALF cases over 24 years. Overall, the number of HAV ALF cases enrolled steeply declined. After 2010, when we began recording acute liver injury (ALI: International normalized ratio ≥ 2 but no encephalopathy), an apparent increase in ALI incidence was noted, despite a near absence of ALF cases.
Medical subject headings
- Liver Failure, Acute
- Hepatitis A