Developing sex-accurate cell culture environments.

Borelli, Alexandra N; Masters, Kristyn S · Nat Rev Bioeng · 2025

basic_science · Level V

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Abstract

The extracellular matrix remains under-recognized as a sex-dependent entity. Designing culture environments that account for sex as a biological variable requires considering not only cellular sex, but also the usage of sex-specific scaffolds to create a holistically sex-accurate platform.