Asymmetric efficacy of VNS within a single patient with bilateral focal frontal lobe epilepsy: A case report.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 40856832.
- Also identified by DOI 10.1007/s00701-025-06653-x and PMC identifier 12380960.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The lateralized efficacy of vagus nerve stimulation (VNS) remains insufficiently explored. We report a case of drug-resistant epilepsy with bilateral frontal lobe seizure onset, treated with left cervical VNS. Preoperative video- electroencephalogram revealed predominant interictal discharges in the right hemisphere and frequent seizures from both hemispheres. Following VNS, overall seizure frequency decreased. Notably, stereo-electroencephalography performed 15 months postoperatively showed a marked reduction in right-sided seizures, while left-sided seizures remained frequent. This case highlights the potential lateralized effect of VNS in a single patient with bilateral frontal lobe epilepsy, suggesting that VNS may preferentially suppress seizures originating from the right hemisphere.
Medical subject headings
- Epilepsy, Frontal Lobe
- Vagus Nerve Stimulation
- Drug Resistant Epilepsy
- Functional Laterality