Hypercapnia promotes maladaptive airway and vascular remodeling in mice.

Shigemura, Masahiko; Nuñez Santana, Felix L; Casalino-Matsuda, S Marina; Kirchenbuechler, David; Nafikova, Radmila; Chen, Fei; Yu, Zhan; Sokolenko, Yuliana V et al. · J Clin Invest · 2025

basic_science · Level V

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Abstract

CO2 isn't just a gas-it can remodel lungs and worsen COPD, but may be reversible with CO2-lowering therapies.

Medical subject headings