Association between subendocardial viability ratio and cardiovascular events: a cohort study in a Chinese community-based population.

Abstract

Subendocardial viability ratio (SEVR) is an effective indicator for evaluating the balance between myocardial oxygen supply and demand. This study aims to explore the association between SEVR and cardiovascular events and mortality in a Chinese community-based population. Retrospective cohort study. An observational cohort established by Peking University First Hospital across multiple communities in China. A total of 5927 participants without a history of stroke or myocardial infarction (MI) from a Chinese community-based cohort were enrolled. SEVR was measured non-invasively using carotid artery pressure waveforms. Participants were divided into low (SEVR<1.3) and high (SEVR≥1.3) SEVR groups. The endpoints included major adverse cardiovascular events (MACEs), comprising all-cause mortality, stroke and MI. Cox proportional hazards models were used to analyse the association between SEVR and endpoints. The mean age of participants was 62.12±7.65 years. Over a mean follow-up of 3.23±0.36 years, 207 (3.49%) participants experienced MACE, including 54 (0.91%) deaths, 134 (2.26%) strokes and 38 (0.64%) MIs. After adjusting for risk factors, each one-unit increase in SEVR significantly reduced the risks of adverse cardiovascular events: MACE decreased by 48% (HR 0.52, 95% CI 0.28 to 0.96), all-cause mortality decreased by 71% (HR 0.29, 95% CI 0.08 to 0.99) and stroke decreased by 57% (HR 0.43, 95% CI 0.20 to 0.91). In participants aged≥65 years, higher SEVR was significantly associated with a reduced MACE risk (HR 0.24, 95% CI 0.11 to 0.53). SEVR was an independent predictor of cardiovascular events in this community-based population. Higher SEVR was significantly associated with lower MACE risk, particularly in older adults.