Even at 100+: Acute Exercise Modulates Inflammatory Pathways in Centenarians.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 40874701.
- Also identified by DOI 10.1111/acel.70152 and PMC identifier 12419837.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Centenarians exhibit remarkable disease resilience despite chronic low-grade inflammation. We investigated the inflammation-related proteome response to acute exercise in seven centenarians (100-104 years). Exercise downregulated 52 proteins (e.g., TNF, IL10, IL1RN, CCL family members) involved in immune cell trafficking, apoptosis, and cytokine regulation. Even at the extreme end of the lifespan, humans retain molecular responsiveness to exercise, with modulation of inflammation-related pathways.
Medical subject headings
- Exercise
- Inflammation