Recent Advances of Aggregation-Induced Emission Luminogens in Atherosclerotic Cardiovascular Disease.

Abstract

Atherosclerotic cardiovascular disease (ASCVD), the primary cause of mortality worldwide, is distinguished by the development of atherosclerotic plaques due to lipid accumulation in the artery wall, ultimately resulting in a range of severe cardiovascular and cerebrovascular complications. In recent years, aggregation-induced emission luminogens (AIEgens), which possess the advantages of fluorescence enhancement in aggregated states, exceptional photostability, and finely tunable biocompatibility, have emerged as a promising candidate for the diagnosis and treatment of ASCVD. This review systematically summarizes the research advancements of AIEgens in ASCVD over the past five years, mainly including the properties of AIEgens and the design for ASCVD management, the application of AIEgens in ASCVD biomarkers sensing, imaging and treatment of ASCVD. Additionally, the existing challenges of AIEgens in ASCVD are discussed, and the prospects are also proposed.