Efficacy of Prophylactic Agents in Preventing Adhesive Small Bowel Obstruction: A Systematic Review and Meta-Analysis.

Huy, Tess C; Bercz, Aron P; Bailey, Angela M; Christensen, Reid R; Eng, Isabel K; Girgis, Mark D; Carmichael, Samuel P; Ko, Clifford Y et al. · J Am Coll Surg · 2026

meta_analysis · Level I

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Abstract

We identified 12 randomized controlled trials and 14 observational studies that were used for meta-analyses. Guardix, but not Seprafilm was associated with reduction in small bowel obstruction. Intraperitoneal agents were not associated with an increased rate of adverse events.