Lewy body dementia promotion by air pollutants.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40906862.
- Also identified by DOI 10.1126/science.adu4132 and PMC identifier 12459341.
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Abstract
Evidence links air pollution to dementia, yet its role in Lewy body dementia (LBD) remains unclear. In this work, we showed in a cohort of 56.5 million individuals across the United States that fine particulate matter (PM<sub>2.5</sub>) exposure raises LBD risk. Mechanistically, we found that PM<sub>2.5</sub> exposure led to brain atrophy in wild-type mice, an effect not seen in α-synuclein (αSyn)-deficient mice. PM<sub>2.5</sub> exposure generated a highly pathogenic αSyn strain, PM<sub>2.5</sub>-induced preformed fibril (PM-PFF), with enhanced proteinase K resistance and neurotoxicity, resembling αSyn LBD strains. PM<sub>2.5</sub> samples from China, the United States, and Europe consistently induced proteinase-resistant αSyn strains and in vivo pathology. Transcriptomic analyses revealed shared responses between PM<sub>2.5</sub>-exposed mice and LBD patients, underscoring PM<sub>2.5</sub>'s role in LBD and stressing the need for interventions to reduce air pollution and its associated neurological disease burden.
Medical subject headings
- Air Pollutants
- alpha-Synuclein
- Brain
- Lewy Body Disease
- Particulate Matter
- Environmental Exposure