Exercise Interventions in Cancer-Related Cognitive Impairment: An Umbrella Review.

Abstract

The aim of this umbrella review is to assess the effectiveness of exercise interventions in preventing and managing cancer-related cognitive impairment among cancer survivors, providing an evidence-based foundation for clinical practice. The umbrella review was preregistered on PROSPERO. It included systematic reviews that assessed any exercise interventions aimed at improving cognition in cancer patients. The overview adhered to gold standard guidelines and recommendations. We utilized AMSTAR 2 to evaluate the quality of the literature and to synthesize the consistency of the evidence in order to formulate recommendations. Based on 28 systematic reviews, four subtypes of exercise interventions were identified. High-quality evidence consistently demonstrates that aerobic exercise significantly improves performance on specific neuropsychological tests. The Hopkins Verbal Learning Test shows a score improvement (standardized mean difference (SMD) = 0.65, 95% confidence interval (CI) = 0.42, 0.88); The Trail Making Test Part A shows a reduction (SMD = -0.61, 95% CI = -0.92, -0.30). Mind-body exercises also have notable effects on alleviating subjective cognitive complaints, indicated by an improvement in the Functional Assessment of Cancer Therapy-Cognitive Function score (SMD = 0.82, 95% CI = 0.49, 1.15). However, the evidence for objective cognitive improvement is limited and inconsistent. Combined training presents preliminary evidence of synergistic effects in enhancing global cognitive function, with an average effect across multiple cognitive domains (SMD = 0.45, 95% CI = 0.20, 0.70). Currently, resistance training lacks robust, high-quality evidence, and more studies are needed to determine its effects on specific objective cognitive domains. This review highlights exercise intervention as a key nonpharmacological approach for managing Cancer-Related Cognitive Impairment. Urgent priorities for future research include the following: (1) conducting high-quality randomized controlled trials to validate exercise tolerability in patients undergoing active treatment; (2) developing multimodal assessment frameworks that integrate neuroimaging and blood-based biomarkers; and (3) establishing personalized exercise guidelines tailored to specific cancer types and treatment phases. Additionally, future studies should focus on clarifying the biological mechanisms that underpin the cognitive improvements associated with exercise. This will help create a stronger evidence base for precision exercise prescription.