From β soloist to endocrine symphony: Subtype-complete islets conduct glucose harmony.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40912231.
- Also identified by DOI 10.1016/j.stem.2025.08.001.
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Abstract
While current stem cell differentiation protocols generate β cell-enriched islets that reverse hyperglycemia post-implantation, they can cause hypoglycemia. Meng et al.<sup>1</sup> reconstruct endocrine subtype-complete islets, which restore counterregulatory responses and protect against hypoglycemia in diabetic mice, highlighting the importance of endocrine diversity in designing physiologically regulated cell therapies for diabetes.
Medical subject headings
- Glucose
- Insulin-Secreting Cells
- Islets of Langerhans