Engineered VTA dopaminergic neurons offer a new path to treating depression.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40912232.
- Also identified by DOI 10.1016/j.stem.2025.08.007.
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Abstract
Dysfunction of A10 midbrain dopaminergic (mDA) neurons is linked to psychiatric disorders, such as depression. In this issue, Yan et al.<sup>1</sup> present an efficient method for differentiating human pluripotent stem cells into A10-like mDA neurons. Activation of grafted A10-like neurons into the mouse mesolimbic circuit alleviates depression-like symptoms.
Medical subject headings
- Dopaminergic Neurons
- Ventral Tegmental Area
- Depression