Ready, set, but no go: Skin fat comes preloaded with waiting precursors.

Shin, Jung-Won; Plikus, Maksim V · Cell Stem Cell · 2025

editorial · Level V

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Abstract

Fat depots across the body dynamically tune their sizes in response to nutrient demands and nonmetabolic cues. Writing in Cell Stem Cell, Rivera-Gonzalez et al.<sup>1</sup> report that skin fat, notable for its ability to rapidly expand, harbors molecularly distinct precursors, primed for proliferation and differentiation into mature adipocytes.

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