Rifampin Exposure in Pregnant and Nonpregnant Women With Tuberculosis in India.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 40925610.
- Also identified by DOI 10.1093/infdis/jiaf467 and PMC identifier 13016651.
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Abstract
This prospective cohort study evaluated rifampin pharmacokinetics in pregnant and nonpregnant women with tuberculosis in India. Pregnant women had significantly lower drug exposure, with <20% of the participants achieving target concentrations at any trimester. Findings highlight potential underdosing in pregnancy and underscore the need for dedicated pharmacokinetics studies in pregnancy, and revised rifampin dosing guidelines.
Medical subject headings
- Rifampin
- Tuberculosis
- Pregnancy Complications, Infectious
- Antitubercular Agents