Are GLP-1 receptor agonists a 'magic bullet' for cancer?

Hebert, James R; Murphy, E Angela; Playdon, Mary C; Makowski, Liza; Ibele, Anna R; Fairman, Ciaran M; Hofseth, Lorne J · Nat Rev Cancer · 2026

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Abstract

Glucagon-like peptide-1 (GLP-1) receptor agonists are widely prescribed for weight loss. Here, we discuss the need to monitor long-term use for cancer risk and to couple dietary and physical activity recommendations to prevent skeletal muscle atrophy and maintain metabolic health among people using these drugs.