Centrifuge-Free Bone Marrow Aspirate Harvest for Orthopaedic Applications.
expert_opinion · Level V
Where this comes from
- Record sourced from PubMed, PMID 40936582.
- Also identified by DOI 10.1016/j.eats.2025.103721 and PMC identifier 12420573.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Autologous bone marrow aspirate (BMA) is increasingly being used in clinical practice to augment the repair and healing of bone, cartilage, and tendon by delivering mesenchymal stem cells (MSCs) and growth factors to the site of injury. Traditional BMA harvest and preparation rely on centrifugation to generate a BMA concentrate with a higher concentration of MSCs than the original aspirate. However, this traditional technique may be inefficient and time-consuming, and it could sacrifice sterility. In this technique, we describe a centrifuge-free BMA harvest system (Marrow Cellution; Cervos Medical) that avoids peripheral blood dilution during aspiration, thereby potentially achieving a higher yield of MSCs and growth factors within the BMA without the need for centrifugation.